Key Laboratories of Shandong University School of Medicine-山东大学基础医学院

The Key Laboratory of Cardiovascular Remodeling and Function Research was established in 2002 and has been designated as a key laboratory by the Chinese Ministry of Education in 2003 and the Chinese Ministry of Health in 2005. There are 53 employees in the institute. Professor Yun Zhang, member of the Chinese Academy of Engineering, is its director.

Since the laboratory’s foundation, it has undertaken 59 research projects. In 2006, the research funding surpassed 45 million RMB. The institute has published more than 600 papers including 56 papers published in SCI journals, such as《Science》,《Blood》,《Arteriosclerosis, Thrombosis, and Vascular Biology》,《American Journal of Cardiology》,《European Heart Journal》,etc. The Key Laboratory of Cardiovascular Remodeling and Function Research has become a well-known research center for cardiovascular diseases.

The principal research fields of the Institute are focused on atherosclerosis, heart failure, arrhythmia, coronary heart disease and thrombus. Under the leadership of Professor Yun Zhang, the Institute is actively involved in international exchanges and collaboration. Over the past three years, 10 researchers have studied in USA, Canada, Japan and Sweden and 36 oral presentations have been made in international conferences. In 2004 and 2006, the institute organized the First and the Second Qilu International Conference of Cardiovascular Diseases, which nearly 1,000 scholars attended. The institute has established international exchange and collaboration with the Baylor Medical College from the USA, the Karolinska Institute from Sweden, and other famous universities or institutes. Our excellent research conditions and free academic atmosphere have attracted many promising young scientists from home and abroad.

2. The Key Laboratory of Experimental Teratology, Ministry of Education, China

The Key Lab of Experimental Teratology became one of key labs of Chinese Ministry of Education in January 2002. Academician Wu Zuze, from Academy of Military Medical Science, is the director of academic committee. Professor Gong Yaoqin, from Institute of Medical Genetics, Shandong University, is the director of the lab.

The Key Lab of Experimental Teratology offers a wide-range programs of study and research leading to Master and Doctoral degree. The research interests of the key lab range from the studies on causes and biological processes leading to abnormal development and birth defects at the fundamental level, to appropriate preventive measures.

We are trying to searching for environmental factors and related genes responsible for congenital malformation. These studies are aimed to understanding the mechanism of congenital malformation and to understanding how to prevent congenital malformation through vaccination and systemic prevention in population.

The specific interestsof the Key Lab's 22 faculty members fall into the following four areas:

Mechanism of congenital malformation

The main research focuses on mechanism of congenital malformation caused by environmental factors and reproduction biology related to congenital malformation.

This lab is led by professor Gao Yingmao. The main research focuses on mechanism of congenital malformation caused by environmental factors and reproduction biology. Their research work use model organisms to illuminate some potential mechanisms involved in the development of neural tube defects(NTD) caused by hyperthermia, environmental drugs, chemicals, and physical agents.

Mapping and identification of genes responsible for congenital diseases

The lab is led by Prof. Gong Yaoqin. The main research fields are mapping, identification and function analysis of genes for common congenital malformation and genetic diseases.They maped and identified the gene responsible for the Osteoporosis-Pseudoglioma Syndrome (OPPG), Brachydactyly type B and Smith-Fineman-Myers syndrome; they found that gene encoding Noggin affects human joint morphogenesis and found that mutations of LRP5 gene are responsible for the Osteoporosis-Pseudoglioma Syndrome (OPPG).

Pathogenic biology of congenital malformation caused by microorganism

This field is leaded by Prof. Yu Xiuping. They mainly study on mechanism and prevention of congenital malformation caused by viruses. They have clarified some underlying molecular mechanisms in overcoming tumorgenesis and have developed some advanced methods to detect and evaluate the function of specific antibody.

Developmental mechanism and gene control of congenital malformation

The lab is led by Pro. Zhang Hongwei, their research focuses on the developmental mechanism of model animal and functions of developmental related genes .They have made contribution to explore early developmental mechanism of amphioxus and the function of hedgehog signal pathway in human tumorigenesis.

3. Key Laboratory of Hematopathy, Shandong Province

The Key Laboratory of Hematopathy has more than 30 clinicians and laboratory researchers. Among them there are seven professors(including five doctoral tutors), six associate professors. The hematology ward has 76 beds for patients, including three laminar flow rooms for hematopoietic stem cell transplantation. The average number of out-patients each year is more than 60,000, and the annual in-patients amount to 1,200.

In the diagnosis of leukemia, our Dept. has established long-term cooperative relations with Sweden's Gothenburg University Blood Center and the South Australia Royal Hospital bone marrow transplant centre and introduced successfully non-myeloablative stem cell transplantation, flow cytometry, tumor cells chromosome analysis technology, MICM typing of leukemia, the real-time quantitative PCR, automatic platelet aggregation detector and other sophisticated technology and equipments. Hemorrhagic diseases have for many years been the focus of study. Under the leadership of Director HOU Ming, our Dept. has introduced a series of advanced diagnostic techniques such as monoclonal antibody-specific immobilization of platelet antigen (MAIPA) assay, to ensure that the diagnosis and treatment of diseases of hemostasis and thrombosis is of high standards.

For the diagnosis and treatment of aplastic anemia, our Dept. is at leading position in the domestic. In lymphoma and multiple myeloma, and other hematologic malignancies we also have extensive experience. The remission rate of lymphoma in our Dept. is near 90 percent and a significant portion of patients eventually cure.

4. Key Laboratory of Medical Neurobiology, Shandong Province

The research on genetic and environmental mechanism of neuropsychiatric disorders has drawn worldwide attention. One important group of the genes involved in neuropsychiatric disorders is the genes encoding neurotrophic factors. Neurotrophic factors are a family of proteins plays a significant role in neuropsychiatric disorders such as depression and substance abuse and have been implicated in the actions of both antidepressants and mood stabilizers. Our group is trying to understand the role of neurotrophic factors in mental disease with combined molecular biology, cellular biology, transgenic mice and animal behavior approaches.

1)Functional analysis of variant BDNF (Val66Met)

2) Intracellular trafficking study of neurotrophic factors and their receptors

Email:zheyuchen@sdu.edu.cn

5. Key Laboratory of Infection and Immunity, Shandong Province

Major Research Interests:

Inflammation and Tumor:main interests are HBV related hepatocellular carcinoma (HCC) and HPV related uterine cervix cancer.

Research on HBV related HCC:We are interested in the carcinogenesis mechanism of HBV, especially HBV coded proteins and try to develop new gene therapy for HCC. Recently we built a novel method to deliver preS2 antisense RNA specifically into hepatocellular carcinoma cells (patent No.03111765.2). Since α-fetoprotein (AFP) is a useful tumor marker for detecting HCC and the expression of AFP was precisely regulated in mammalian. We use AFP as a model to study gene regulation in liver, especially during liver carcinogenesis and try to find more tumor markers.

Research on HPV related uterine cervix cancer:We are interested in the carcinogenesis mechanism of HPV, especially HPV coded proteins and try to develop new vaccines.

Immune regulation in inflammation: main interests are to study the role of immune molecules(such as co-stimulatory molecules, cytokines) in different inflammation related diseases(Hepatitis, Arthrosclerosis，Helicobacter pylori relatedgastritis，sGVHD, etc.)

Email：immuno@sdu.edu.cn

6. The Jinpeng Sun-Xiao Yu Joint Laboratory

The Jinpeng Sun-Xiao Yu joint laboratory was created by Professor Jin-peng Sun from the Department of Biochemistry and Molecular Biology and Professor Xiao Yu from the Department of Physiology at Shandong University, School of Medicine. The joint laboratory shares many resources, including molecular biology, biochemistry, crystallography, electro-physiology and animal models. The laboratory has a broad research interest, including membrane receptors, protein post-translational modifications and their functional relevance in physiological or pathological contexts.The joint laboratory is located at the Baotu Spring campus of Shandong University,near the famous Baotu Spring. The scenery is beautiful, especially in the summer; and the history is long.The joint laboratory is looking for highly motivated students or scientific researchers to elucidate the molecular mechanisms underlying important human diseases and to develop effective therapies to treat these diseases.

Professor Xiao Yu was admitted to the Special Class for the Gifted and Young (SCGY) at the University of Science and Technology of China (USTC) in 1994 and earned her Bachelor of Science degree together with the excellent undergraduate class of Anhui Province in 1999. She then studied electro-physiology with Professor Zhuan Zhou (the student of Nobel Prize winner Erwin Neher) at the Institute of Neuroscience, CAS. Professor Xiao Yu completed her Ph.D. in 2004 and then worked as a research associate at the University of Stony Brook and Indiana University from 2004 to 2009. Professor Xiao Yu set up her own laboratory in 2009 at Shandong University. She has earned the 21stCentury Excellent Scientist of Education award from the Department of China and was named an Excellent Young Scientist by Shandong Province. Professor Xiao Yu is also the principle investigator of the high school key laboratory of Shandong University entitled “Protein Science of degenerative diseases”. To date, Professor Xiao Yu has published more than 30 research papers in high impact journals, such asPNAS, J.Biol.Chem, J. Neurosci, J. Physiol, Diabetes, JACS, AJPCP .

Professor Jinpeng Sun entered the University of Science and Technology of China (USTC) in 1993. In 1997, he began studying protein crystallography with Professor Li wen Niu and Professor Mai kun Teng. In 2001, Professor Yun Yu Shi (CAS member of China) recommended that hestudy protein tyrosine phosphatases with Professor Zhong yin Zhang at Albert Einstein College of Medicine (AECOM). Jin-peng earned his Ph.D. at AECOM in 2006 and continued his research under Professor Zhong-yin’s supervision until 2007. He then studied G protein coupled receptors at Duke University with Professor Robert J. Lefkowitz (HHMI, NAS member, 2012 Nobel Prize). After 4 years, Jin-peng came to the Department of Biochemistry and Molecular Biology at Shandong University to set up his own laboratory. To date, Professor Jin-peng Sun has published more than 30 research papers in journals such asJ.Biol.Chem, PNAS, Biochemistry, Nature Biotechnology, Nature Chemical Biology, and Angew Chem Int Ed Engl.